(1S,2S)-2-aminocyclohexanol → 1,5-Anhydro-3-(5-bromo-7-oxo-1,8-phenanthrolin-8(7H)-yl)-2,3-dideoxy-L-threo-pentitol

HRID 1042626Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1042626
[Br:1][C:2]1[CH:15]=[C:14]2[C:9]([CH:10]=[CH:11][N:12]([C@H:17]3[CH2:22][CH2:21]C[CH2:19][C@@H:18]3[OH:23])[C:13]2=[O:16])=[C:8]2[C:3]=1[CH:4]=[CH:5][CH:6]=[N:7]2.N[C@H]1CCCC[C@@H]1[OH:31]>>[Br:1][C:2]1[CH:15]=[C:14]2[C:9]([CH:10]=[CH:11][N:12]([C@@H:17]3[C@@H:18]([OH:23])[CH2:19][O:31][CH2:21][CH2:22]3)[C:13]2=[O:16])=[C:8]2[C:3]=1[CH:4]=[CH:5][CH:6]=[N:7]2

Komponenten

3

Edukt 2

HCID 7057408(1S,2S)-2-aminocyclohexanolHCID 866836985-bromo-8-[(1S,2S)-2-hydroxycyclohexyl]-1,8-phenanthrolin-7(8H)-one

Produkt 1

HCID 866836971,5-Anhydro-3-(5-bromo-7-oxo-1,8-phenanthrolin-8(7H)-yl)-2,3-dideoxy-L-threo-pentitol

Versuchsvorschrift

1,5-Anhydro-3-(5-bromo-7-oxo-1,8-phenanthrolin-8(7H)-yl)-2,3-dideoxy-L-threo-pentitol was prepared by the procedure described for the synthesis of 5-bromo-8-[(1S,2S)-2-hydroxycyclohexyl]-1,8-phenanthrolin-7(8H)-one in Example 1, substituting (3R,4S)-4-aminotetrahydro-2H-pyran-3-ol for (1S,2S)-2-aminocyclohexanol.

Quellen und Nachweise

ORD-Eintrag
ord-09efeefc06f7492da2b7e41433c146b8
Quelldatensatz
uspto-grants-2013_10
Patentnummer
US08557992B2

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