3-Chloropropionyl chloride → 2-(Trifluoromethyl)-5,6,7,8-tetrahydro-1,6-naphthyridine

HRID 1043823

Reaktionsgleichung

Reaktionsgleichung von HRID 1043823
C([N:8]1[CH2:17][CH2:16][C:15]2[N:14]=[C:13]([C:18]([F:21])([F:20])[F:19])[CH:12]=[CH:11][C:10]=2[CH2:9]1)C1C=CC=CC=1.ClCCC(Cl)=O>ClCCl>[F:21][C:18]([F:19])([F:20])[C:13]1[CH:12]=[CH:11][C:10]2[CH2:9][NH:8][CH2:17][CH2:16][C:15]=2[N:14]=1

Komponenten

4

Edukt 2

HCID 693643-Chloropropionyl chlorideHCID 577709166-Benzyl-2-(trifluoromethyl)-5,6,7,8-tetrahydro-1,6-naphthyridine

Produkt 1

HCID 534719842-(Trifluoromethyl)-5,6,7,8-tetrahydro-1,6-naphthyridine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Reaktionsbedingungen

Temperatur
40 °C

Versuchsvorschrift

To a solution of 5 (500 mg, 1.7 mmol) in dichoromethane (8 mL) was added compound 6, 3-chloro propionyl chloride (0.22 mL, 2.1 mmol) and the reaction mixture was stirred at 40° C. for 18 h. The reaction was then cooled to room temperature and concentrated. The resulting residue was dissolved in methanol (16 mL) and stirred at 40° C. for 3 h. The mixture was then cooled to room temperature and concentrated.

Aufarbeitung

  1. temperatureThe reaction was then cooled to room temperature
  2. concentrationconcentrated
  3. dissolutionThe resulting residue was dissolved in methanol (16 mL)
  4. stirringstirred at 40° C. for 3 h
  5. temperatureThe mixture was then cooled to room temperature
  6. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-ea0d4bec166348a088b680e664e78c47
Quelldatensatz
uspto-grants-2013_10
Patentnummer
US08563566B2

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