1,4-Dioxane hydrochloride → (3SR,4RS)-4-hydrazinyltetrahydrofuran-3-ol hydrochloride

HRID 1043885

Reaktionsgleichung

Reaktionsgleichung von HRID 1043885
O1CCOCC1.[ClH:7].[OH:8][CH:9]1[CH2:13][O:12][CH2:11][CH:10]1[NH:14][NH:15]C(OC(C)(C)C)=O>CO>[ClH:7].[NH:14]([CH:10]1[CH2:11][O:12][CH2:13][CH:9]1[OH:8])[NH2:15]

Komponenten

4

Edukt 2

HCID 204431481,4-Dioxane hydrochlorideHCID 86686323t-butyl 2-((3RS,4SR)-4-hydroxytetrahydrofuran-3-yl)hydrazinecarboxylate

Produkt 1

HCID 86686324(3SR,4RS)-4-hydrazinyltetrahydrofuran-3-ol hydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

A 4 M hydrogen chloride-1,4-dioxane solution (50 mL) was added to a solution of t-butyl 2-((3RS,4SR)-4-hydroxytetrahydrofuran-3-yl)hydrazinecarboxylate (5.78 g) in methanol (30 mL) under ice-cooling, and the mixture was then warmed to room temperature and stirred overnight. The reaction mixture was concentrated to give the title compound (5 g).

Aufarbeitung

  1. temperaturecooling
  2. concentrationThe reaction mixture was concentrated

Quellen und Nachweise

ORD-Eintrag
ord-2a0fc353c9dd48bfa2d7ccc7df69d076
Quelldatensatz
uspto-grants-2013_10
Patentnummer
US08563565B2

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