Cetirizine → Cetirizine Fluticasone

HRID 1045324

Reaktionsgleichung

Reaktionsgleichung von HRID 1045324
[CH:1]1[CH:2]=[CH:3][C:4]([CH:7]([N:15]2[CH2:20][CH2:19][N:18]([CH2:21][CH2:22][O:23][CH2:24][C:25]([OH:27])=[O:26])[CH2:17][CH2:16]2)[C:8]2[CH:9]=[CH:10][C:11]([Cl:14])=[CH:12][CH:13]=2)=[CH:5][CH:6]=1.[CH3:28][C@H:29]1[C@:46]([OH:52])([C:47]([S:49][CH2:50][F:51])=[O:48])[C@:45]2([CH3:53])[C@H:31]([C@H:32]3[C@:42]([F:55])([C@@H:43]([OH:54])[CH2:44]2)[C@:41]2([CH3:56])[C:35](=[CH:36][C:37]([CH:39]=[CH:40]2)=[O:38])[C@@H:34]([F:57])[CH2:33]3)[CH2:30]1>>[CH:1]1[CH:2]=[CH:3][C:4]([CH:7]([N:15]2[CH2:20][CH2:19][N:18]([CH2:21][CH2:22][O:23][CH2:24][C:25]([OH:27])=[O:26])[CH2:17][CH2:16]2)[C:8]2[CH:9]=[CH:10][C:11]([Cl:14])=[CH:12][CH:13]=2)=[CH:5][CH:6]=1.[CH3:28][C@H:29]1[C@:46]([OH:52])([C:47]([S:49][CH2:50][F:51])=[O:48])[C@:45]2([CH3:53])[C@H:31]([C@H:32]3[C@:42]([F:55])([C@@H:43]([OH:54])[CH2:44]2)[C@:41]2([CH3:56])[C:35](=[CH:36][C:37]([CH:39]=[CH:40]2)=[O:38])[C@@H:34]([F:57])[CH2:33]3)[CH2:30]1

Komponenten

3

Edukt 2

HCID 2678Cetirizine2×HCID 5311101Fluticasone2×

Produkt 1

HCID 131730919Cetirizine Fluticasone

Versuchsvorschrift

The purpose of this example was to evaluate the efficacy of cetirizine 0.1%/fluticasone 0.005% ophthalmic suspension compared to cetirizine 0.1% ophthalmic suspension, fluticasone 0.005% ophthalmic suspension and vehicle in the prevention of the signs and symptoms of allergic conjunctivitis in a modified CAC model.

Quellen und Nachweise

ORD-Eintrag
ord-14ee4efaa114404cba65dbe412644580
Quelldatensatz
uspto-grants-2013_10
Patentnummer
US08569273B2

Verknüpfte Notizen

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