Pyridine → 3'-Methylcinnamanilide

HRID 1045353

Reaktionsgleichung

Reaktionsgleichung von HRID 1045353
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([CH3:8])[CH:3]=1.N1C=CC=CC=1.[C:15](Cl)(=[O:24])[CH:16]=[CH:17][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1>ClCCl>[C:4]1([CH3:8])[CH:5]=[CH:6][CH:7]=[C:2]([NH:1][C:15](=[O:24])[CH:16]=[CH:17][C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)[CH:3]=1

Komponenten

5

Edukt 3

HCID 1049PyridineHCID 7934m-ToluidineHCID 660233-Phenylprop-2-enoyl chloride

Produkt 1

HCID 5830183'-Methylcinnamanilide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Reaktionsbedingungen

Temperatur
0 °C

Versuchsvorschrift

m-Toluidine (5 g, 46.64 mmol) and pyridine (3.77 mL, 46.64 mmol) were dissolved in dry dichloromethane (25 mL). To the reaction mixture, cinnamoyl chloride (7.72 g, 46.64 mmol) was added and stirred for 3 h at 0° C. The reaction mixture was extracted with dichloromethane washing with water and 2N HCl. The solvent was removed and the crude product was used in the next step without further purification.

Aufarbeitung

  1. extractionThe reaction mixture was extracted with dichloromethane washing with water and 2N HCl
  2. customThe solvent was removed
  3. customthe crude product was used in the next step without further purification

Quellen und Nachweise

ORD-Eintrag
ord-14ca28f2f70a417195f49f94d34eea8b
Quelldatensatz
uspto-grants-2013_10
Patentnummer
US08569282B2

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