Hydrochloric Acid → 3,3,3-trifluoro-N-(4-{[3-(4-methoxybenzyl)-2-oxo-1,2,3,4-tetrahydropyrido[2,3-d]pyrimidin-5-yl]amino}phenyl)propanamide

Beteiligte Stoffe

Rolle	Name	HCID	Einwaage
Edukt	Hydrochloric Acid	HCID 313	—
Edukt	N-(4-Aminophenyl)-3,3,3-trifluoropropanamide	HCID 16772763	—
Edukt	5-chloro-3-[(4-methoxyphenyl)methyl]-1H,2H,3H,4H-pyrido[2,3-d]pyrimidin-2-one	HCID 66926291	—
Lösungsmittel	N-methyl-2-pyrrolidone	HCID 13387	—
Produkt	3,3,3-trifluoro-N-(4-{[3-(4-methoxybenzyl)-2-oxo-1,2,3,4-tetrahydropyrido[2,3-d]pyrimidin-5-yl]amino}phenyl)propanamide	HCID 70497675	39%

Reaktionsbedingungen

Temperatur	150 °C

Reaktionsschritte

1 (52 mg, 0.17 mmol), N-(4-aminophenyl)-3,3,3-trifluoropropanamide (44 mg, 0.17 mmol), and HCl (43 μL, 4.0M in dioxane, 0.17 mmol) were suspended in NMP (1 mL), and stirred in a microwave at 150° C. for 100 min. The crude product was purified directly via HPLC to provide 100 (39% yield). LC-MS (M+H=486, obsd.=486).

Herkunft & Nachweise

DOI	10.6084/m9.figshare.5104873.v1
Patentnummer	US08569295B2
Quelldatensatz	uspto-grants-2013_10
ORD ID	ord-60256fb045ff4a20a61ae4daad342a47
Quellennotiz	uspto-grants-2013_10