Hydrochloric Acid → 2-Benzylpyrrolidine

HRID 1045701

Reaktionsgleichung

Reaktionsgleichung von HRID 1045701
C(OC([N:8]1[CH2:12][CH2:11][CH2:10][CH:9]1[CH2:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)=O)(C)(C)C.Cl>C(OCC)(=O)C>[CH2:13]([CH:9]1[CH2:10][CH2:11][CH2:12][NH:8]1)[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 3265841(2RS)-2-benzyl-pyrrolidine-1-carboxylic acid tert-butyl ester

Produkt 1

HCID 3395562-BenzylpyrrolidineAusbeute 94,4 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8857Ethyl AcetateLösungsmittel2×

Versuchsvorschrift

To a solution of (2RS)-2-benzyl-pyrrolidine-1-carboxylic acid tert-butyl ester (1.21 g, 4.6 mmol) in ethyl acetate (20 ml) was added hydrogen chloride (4N) in ethyl acetate (20 ml) at room temperature. The mixture was stirred at room temperature for 2 hours and was concentrated. The residue was partitioned between aqueous sodium hydrogen carbonate and chloroform, and the organic layer was dried over sodium sulfate. The solvent was evaporated under reduced pressure to afford (2RS)-2-benzyl-pyrrolidine (0.7 g, 93%).

Aufarbeitung

  1. concentrationwas concentrated
  2. customThe residue was partitioned between aqueous sodium hydrogen carbonate and chloroform
  3. dry with materialthe organic layer was dried over sodium sulfate
  4. customThe solvent was evaporated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-68f54c6d5a424369b8b935b679581ef7
Quelldatensatz
uspto-grants-2013_10
Patentnummer
US08569294B2

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