Dimethylformamide dimethyl acetal → HCID 58447035, Verbindung

HRID 1045772Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1045772
[NH2:1][C:2]1[C:7]([Br:8])=[CH:6][N:5]=[C:4]([N:9]2[CH2:14][CH2:13][N:12]([C:15]([O:17][C:18]([CH3:21])([CH3:20])[CH3:19])=[O:16])[CH2:11][CH2:10]2)[N:3]=1.CO[CH:24](OC)[N:25]([CH3:27])[CH3:26]>C1(C)C=CC=CC=1>[Br:8][C:7]1[C:2]([N:1]=[CH:24][N:25]([CH3:27])[CH3:26])=[N:3][C:4]([N:9]2[CH2:10][CH2:11][N:12]([C:15]([O:17][C:18]([CH3:21])([CH3:20])[CH3:19])=[O:16])[CH2:13][CH2:14]2)=[N:5][CH:6]=1

Komponenten

4

Edukt 2

HCID 78373Dimethylformamide dimethyl acetalHCID 58446994HCID 58446994, Verbindung

Produkt 1

HCID 58447035HCID 58447035, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1140TolueneLösungsmittel

Versuchsvorschrift

A 100 mL round bottom flask was charged with tert-butyl 4-(4-amino-5-bromopyrimidin-2-yl)piperazine-1-carboxylate (2.0 g, 5.6 mmol), N,N-dimethylformamide dimethyl acetal (0.9 g, 7.3 mmol) and toluene (60 mL). The resulting mixture was heated at reflux for 12 h. Work-up: the solvent was evaporated to dryness to afford the product, which was used in the next step without further purification.

Aufarbeitung

  1. temperatureThe resulting mixture was heated
  2. temperatureat reflux for 12 h
  3. customthe solvent was evaporated to dryness
  4. customto afford the product, which
  5. customwas used in the next step without further purification

Quellen und Nachweise

ORD-Eintrag
ord-33572f8187cf4917a0b1be68b2747ef4
Quelldatensatz
uspto-grants-2013_10
Patentnummer
US08569300B2

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