Trifluoroacetic acid → 5-Bromo-6-methylpicolinamide

HRID 1047263Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1047263
[Br:1][C:2]1[CH:3]=[CH:4][C:5]([C:9]#[N:10])=[N:6][C:7]=1[CH3:8].C(O)(C(F)(F)F)=[O:12]>S(=O)(=O)(O)O>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([C:9]([NH2:10])=[O:12])=[N:6][C:7]=1[CH3:8]

Komponenten

4

Edukt 2

HCID 6422Trifluoroacetic acidHCID 498187795-Bromo-6-methylpyridine-2-carbonitrile

Produkt 1

HCID 666077245-Bromo-6-methylpicolinamideAusbeute 54 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1118Sulfuric AcidLösungsmittel

Reaktionsbedingungen

Temperatur
40 °C

Versuchsvorschrift

A solution of 5-bromo-6-methylpicolinonitrile (1.8 g, 9.14 mmol) in a mixture of TFA and sulfuric acid (30 mL, 4:1, V/V) was stirred at 40° C. for 16 h. The reaction mixture was poured into ice water. The resulting solid was filtered off and washed with water and dried to give the desired product as a white solid (1.0 g, 4.65 mmol, 54% yield). MS (ESI) m/z 217.1 [M+2]+.

Aufarbeitung

  1. filtrationThe resulting solid was filtered off
  2. washwashed with water
  3. customdried

Quellen und Nachweise

ORD-Eintrag
ord-b53bda615aa34c9e91b05a7642a5b72d
Quelldatensatz
uspto-grants-2013_10
Patentnummer
US08569494B2

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