Trifluoroacetic acid → HCID 136232546, Verbindung
Reaktionsgleichung
C(O)(C(F)(F)F)=O.[F:8][C:9]1([F:45])[CH2:11][CH:10]1[C:12]([NH:14][C:15]1[CH:23]=[CH:22][CH:21]=[C:20]2[C:16]=1[C:17]([C:30]1[NH:34][C:33]3[CH:35]=[CH:36][C:37]([N:39]4[CH2:44][CH2:43][O:42][CH2:41][CH2:40]4)=[CH:38][C:32]=3[N:31]=1)=[N:18][N:19]2C1CCCCO1)=[O:13]>C(Cl)Cl>[F:45][C:9]1([F:8])[CH2:11][CH:10]1[C:12]([NH:14][C:15]1[CH:23]=[CH:22][CH:21]=[C:20]2[C:16]=1[C:17]([C:30]1[NH:31][C:32]3[CH:38]=[C:37]([N:39]4[CH2:40][CH2:41][O:42][CH2:43][CH2:44]4)[CH:36]=[CH:35][C:33]=3[N:34]=1)=[N:18][NH:19]2)=[O:13]Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
TFA (327 mg, 2.87 mmol) was added to solution of 2,2-difluoro-N-(3-(5-morpholino-1H-benzo[d]imidazol-2-yl)-1-(tetrahydro-2H-pyran-2-yl)-1H-indazol-4-yl)cyclopropane carboxamide (15 mg, 0.029 mmol) in CH2Cl2 (5 mL). The reaction mixture was stirred overnight at room temperature, and then the solvent was removed in vacuo. Purification by flash chromatography (5% CH3OH/CH2Cl2) afforded the title compound (8 mg) as a solid. 1H NMR: (400 MHz, CD3OD): δ 8.18 (d, 1H, J=8.0 Hz), 7.49 (d, 1H, J=8.8 Hz), 7.35 (m, 1H), 7.25 (d, 1H, J=8.0 Hz), 7.18 (s, 1H), 7.09 (d, 1H, J=7.6 Hz), 3.89 (m, 4H), 3.22 (m, 4H), 3.08-3.01 (m, 1H), 2.21-2.15 (m, 1H), 1.96 (m, 1H); ESI-MS [M+H]+: 439.1.