Dimethyl Sulfate → 1-(2-Methyl-3-trifluoromethylphenyl)-4-methyl-1,4-dihydrotetrazol-5-one
Reaktionsgleichung
[CH3:1][C:2]1[C:7]([C:8]([F:11])([F:10])[F:9])=[CH:6][CH:5]=[CH:4][C:3]=1[N:12]1[C:16](=[O:17])[NH:15][N:14]=[N:13]1.[C:18](=O)([O-])[O-].[K+].[K+].S(OC)(OC)(=O)=O.C(=O)(O)[O-].[Na+]>CN(C)C=O>[CH3:1][C:2]1[C:7]([C:8]([F:9])([F:10])[F:11])=[CH:6][CH:5]=[CH:4][C:3]=1[N:12]1[C:16](=[O:17])[N:15]([CH3:18])[N:14]=[N:13]1Komponenten
6
Edukt 4
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Reaktionsbedingungen
- Temperatur
- 25 °C
Versuchsvorschrift
A mixture of 1-(2-methyl-3-trifluoromethylphenyl)-1,4-dihydrotetrazole-5-one, potassium carbonate 11.20 g, dimethyl sulfate 3.71 g and N,N-dimethylformamide 150 mL was stirred at 25° C. for one hour. To the reaction mixtures was added aqueous saturated sodium bicarbonate solution and the mixtures were extracted with ethyl acetate. The organic layers were washed with aqueous saturated sodium bicarbonate solution and were dried over anhydrous sodium sulfate. The resulting mixtures were concentrated under reduced pressure to give 1-(2-methyl-3-trifluoromethylphenyl)-4-methyl-1,4-dihydrotetrazole-5-one 5.13 g.
Aufarbeitung
- customTo the reaction mixtures
- extractionthe mixtures were extracted with ethyl acetate
- washThe organic layers were washed with aqueous saturated sodium bicarbonate solution
- dry with materialwere dried over anhydrous sodium sulfate
- concentrationThe resulting mixtures were concentrated under reduced pressure
Quellen und Nachweise
- ORD-Eintrag
- ord-413944e88aa3430ea8aa7ef4a07e26e8
- Quelldatensatz
- uspto-grants-2016_07
- Patentnummer
- US09380782B2
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