Serinol → N1,N3-bis(1,3-dihydroxypropan-2-yl)-5-nitroisophthalamide

HRID 1048831

Reaktionsgleichung

Reaktionsgleichung von HRID 1048831
[N+:1]([C:4]1[CH:5]=[C:6]([C:14]([O:16]C)=O)[CH:7]=[C:8]([CH:13]=1)[C:9]([O:11]C)=O)([O-:3])=[O:2].[NH2:18][CH:19]([CH2:22][OH:23])[CH2:20][OH:21]>CO>[OH:21][CH2:20][CH:19]([NH:18][C:9](=[O:11])[C:8]1[CH:13]=[C:4]([N+:1]([O-:3])=[O:2])[CH:5]=[C:6]([C:14]([NH:18][CH:19]([CH2:22][OH:23])[CH2:20][OH:21])=[O:16])[CH:7]=1)[CH2:22][OH:23]

Komponenten

4

Edukt 2

HCID 68294SerinolHCID 83316Dimethyl 5-nitroisophthalate

Produkt 1

HCID 89544897N1,N3-bis(1,3-dihydroxypropan-2-yl)-5-nitroisophthalamideAusbeute 99,7 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Reaktionsbedingungen

Temperatur
20 °C

Versuchsvorschrift

Dimethyl 5-nitroisophthalate (120 g, 0.5 mol) and serinol (113.6 g, 1.25 mol) are dissolved in methanol (960 mL), and then heated to reflux for 48 h. Cooled to 20° C., the solid is collected filtration using vacuum and the filter cake washed with methanol (50 mL×3). The filter cake is then dried to constant weight to obtain 178.2 g product as a white powder in 99% yield.

Aufarbeitung

  1. temperatureheated
  2. temperatureto reflux for 48 h
  3. customthe solid is collected
  4. filtrationfiltration
  5. washthe filter cake washed with methanol (50 mL×3)
  6. customThe filter cake is then dried to constant weight

Quellen und Nachweise

ORD-Eintrag
ord-2b1457a970c64d9795b2a37ccee18817
Quelldatensatz
uspto-grants-2016_07
Patentnummer
US09382194B2

Verknüpfte Notizen

Wird geladen…