Hydrochloride methanol → HCID 11293051, Verbindung

HRID 10492

Reaktionsgleichung

Reaktionsgleichung von HRID 10492
C(OC([NH:8][CH2:9][CH2:10][CH2:11][N:12]([S:22]([C:25]1[CH:34]=[CH:33][CH:32]=[C:31]2[C:26]=1[CH:27]=[CH:28][N:29]=[CH:30]2)(=[O:24])=[O:23])[CH2:13][CH2:14][CH2:15][C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)=O)(C)(C)C.[ClH:35].CO>>[ClH:35].[CH:30]1[C:31]2[C:26](=[C:25]([S:22]([N:12]([CH2:13][CH2:14][CH2:15][C:16]3[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=3)[CH2:11][CH2:10][CH2:9][NH2:8])(=[O:23])=[O:24])[CH:34]=[CH:33][CH:32]=2)[CH:27]=[CH:28][N:29]=1

Komponenten

3

Edukt 2

HCID 21893726Hydrochloride methanolHCID 21979966N-(tert-butoxycarbonyl)-N'-[(5-isoquinolyl)sulfonyl]-N'-(3-phenylpropyl)-1,3-propylenediamine

Produkt 1

HCID 11293051HCID 11293051, Verbindung

Versuchsvorschrift

Intermediate 2 (913 mg) was added with 10% hydrogen chloride/methanol solution (18 ml, Tokyo Kasei Kogyo) at room temperature and stirred for 25 minutes under reflux by heating. After the reaction, the solvent was evaporated under reduced pressure, and the residue was crystallized from a mixed solvent of methanol and diethyl ether to obtain the title compound (653 mg).

Aufarbeitung

  1. temperatureunder reflux
  2. temperatureby heating
  3. customAfter the reaction
  4. customthe solvent was evaporated under reduced pressure
  5. customthe residue was crystallized from a mixed solvent of methanol and diethyl ether

Quellen und Nachweise

ORD-Eintrag
ord-62100151a08f44888e9b9f008aa8d719
Quelldatensatz
uspto-grants-2006_08
Patentnummer
US07094789B2

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