Dimethylformamide dimethyl acetal → 4-((1E)-2-(Dimethylamino)ethenyl)-3-pyridinecarbonitrile
Reaktionsgleichung
[CH3:1][N:2]([CH:4](OC)OC)[CH3:3].[CH3:9][C:10]1[C:15]([C:16]#[N:17])=[CH:14][N:13]=[CH:12][CH:11]=1>CN(C=O)C>[CH3:1][N:2]([CH3:3])/[CH:4]=[CH:9]/[C:10]1[C:15]([C:16]#[N:17])=[CH:14][N:13]=[CH:12][CH:11]=1Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Reaktionsbedingungen
- Temperatur
- 35 °C
Versuchsvorschrift
940 ml of DMF dimethyl acetal are added to a solution of 200 g of 4-methylnicotinonitrile in 940 g of DMF, and the mixture is heated under reflux at 120-110 for 3 days. The mixture is cooled to 35° C., poured into 10 liters of ice-water and cooled at 4° C. for 16 h. The precipitate is filtered off, washed with water and dried, giving 263 g of 4-((E)-2-dimethylaminovinyl)nicotinonitrile; M˜173.22 g/mol; M+H found 174, NMR corresponds.