Hydrochloride methanol → HCID 21979812, Verbindung

HRID 10494Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 10494
C(OC([NH:8][CH2:9][CH2:10][CH2:11][N:12]([S:23]([C:26]1[CH:35]=[CH:34][CH:33]=[C:32]2[C:27]=1[CH:28]=[CH:29][N:30]=[CH:31]2)(=[O:25])=[O:24])[CH2:13][CH2:14][CH2:15][CH2:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)=O)(C)(C)C.[ClH:36].CO>>[ClH:36].[CH:31]1[C:32]2[C:27](=[C:26]([S:23]([N:12]([CH2:13][CH2:14][CH2:15][CH2:16][C:17]3[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=3)[CH2:11][CH2:10][CH2:9][NH2:8])(=[O:24])=[O:25])[CH:35]=[CH:34][CH:33]=2)[CH:28]=[CH:29][N:30]=1

Komponenten

3

Edukt 2

HCID 21893726Hydrochloride methanolHCID 21979838N-(tert-butoxycarbonyl)-N'-[(5-isoquinolyl)sulfonyl]-N'-(4-phenylbutyl)-1,3-propylenediamine

Produkt 1

HCID 21979812HCID 21979812, Verbindung

Versuchsvorschrift

According to the method of Example 1, Step C, deprotection was performed (50° C., 2 hours) by using Intermediate 6 (249 mg) and 10% hydrogen chloride/methanol solution (5 ml). The reaction mixture was cooled to room temperature, and then the solvent was evaporated under reduced pressure. The residue was added with methanol (1 ml) and diethyl ether (3 ml). The deposited precipitates were collected by filtration and washed with diethyl ether to obtain the title compound (188 mg) as white powdery solid.

Aufarbeitung

  1. custom(50° C., 2 hours)
  2. customthe solvent was evaporated under reduced pressure
  3. additionThe residue was added with methanol (1 ml) and diethyl ether (3 ml)
  4. customThe deposited precipitates
  5. filtrationwere collected by filtration
  6. washwashed with diethyl ether

Quellen und Nachweise

ORD-Eintrag
ord-40e9753b7e624fac9a959e0125d91815
Quelldatensatz
uspto-grants-2006_08
Patentnummer
US07094789B2

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