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HRID 1049751Erstellt: 23. Oktober 2026

Fibric acid → 5-[4-(2-Methyl-2-phenoxypropionylamino)phenyl]-1H-naphtho[1,2-b][1,4]diazepine-2,4(3H,5H)-dione

https://huagongshe.com/de/reaction/1049751

Reaktionsgleichung

Beteiligte Stoffe

RolleNameHCIDEinwaage
EduktFibric acidHCID 70343—
Edukt2-Methyl-2-phenoxypropanoyl chlorideHCID 13111191—
Edukt5-(4-Aminophenyl)-1H-naphtho[1,2-b][1,4]diazepine-2,4(3H,5H)-dioneHCID 117699167—
Produkt5-[4-(2-Methyl-2-phenoxypropionylamino)phenyl]-1H-naphtho[1,2-b][1,4]diazepine-2,4(3H,5H)-dioneHCID 117699411101%

Reaktionsschritte

2-Methyl-2-phenoxypropionic acid (34 mg, 0.189 mmol) was made into acid chloride in a conventional manner. By using 5-(4-aminophenyl)-1H-naphtho[1,2-b][1,4]diazepine-2,4(3H,5H)-dione (30 mg, 0.095 mmol) obtained in Example 1, (3), and 2-methyl-2-phenoxypropionic acid chloride mentioned above, the title compound (46 mg, yield 100%) was obtained in the same manner as that of Example 1.

Herkunft & Nachweise

DOI10.6084/m9.figshare.5104873.v1
PatentnummerUS09382236B2
Quelldatensatzuspto-grants-2016_07
ORD IDord-45d02ea71e07441a86152a3515942101
Quellennotizuspto-grants-2016_07