HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
3-(2-Methylphenyl)propanoyl chloride → 5-[4-[3-(2-Methylphenyl)propionylamino]phenyl]-1H-naphtho[1,2-b][1,4]diazepine-2,4(3H,5H)-dione
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 3-(2-Methylphenyl)propanoyl chloride | HCID 13029201 | — |
| Edukt | 5-[2-(2-Iodobenzoyl)aminoethyl]-1H-naphtho[1,2-b][1,4]diazepine-2,4(3H,5H)-dione | HCID 117699125 | — |
| Edukt | 5-(4-Aminophenyl)-1H-naphtho[1,2-b][1,4]diazepine-2,4(3H,5H)-dione | HCID 117699167 | — |
| Produkt | 5-[4-[3-(2-Methylphenyl)propionylamino]phenyl]-1H-naphtho[1,2-b][1,4]diazepine-2,4(3H,5H)-dione | HCID 117699410 | 64% |
Reaktionsschritte
By using 5-(4-aminophenyl)-1H-naphtho[1,2-b][1,4]diazepine-2,4(3H,5H)-dione (30 mg, 0.095 mmol) obtained in Example 1, (3), and 3-(2-methylphenyl)propionic acid chloride (0.114 mmol), the title compound (28 mg, yield 64%) was obtained as white crystals in the same manner as that of Example 1, (4).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US09382236B2 |
| Quelldatensatz | uspto-grants-2016_07 |
| ORD ID | ord-9e6ee6af903d451bbe592c82e9241439 |
| Quellennotiz | uspto-grants-2016_07 |