4-Nitropyridine N-oxide → 4-Ethoxypyridine n-oxide

HRID 1050132

Reaktionsgleichung

Reaktionsgleichung von HRID 1050132
[N+]([C:4]1[CH:9]=[CH:8][N+:7]([O-:10])=[CH:6][CH:5]=1)([O-])=O.[CH2:11]([O-:13])[CH3:12].[Na+]>C1COCC1>[CH2:11]([O:13][C:4]1[CH:9]=[CH:8][N+:7]([O-:10])=[CH:6][CH:5]=1)[CH3:12]

Komponenten

4

Edukt 2

HCID 143004-Nitropyridine N-oxideHCID 2723922Sodium ethoxide

Produkt 1

HCID 2524794-Ethoxypyridine n-oxideAusbeute 50,5 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Reaktionsbedingungen

Temperatur
25 °C

Versuchsvorschrift

To a mixture of 4-nitropyridine 1-oxide (28 g, 200 mmol) in THF (50 mL) was added sodium ethanolate (40.8 g, 600 mmol). The mixture was stirred at 25° C. for 16 h. The reaction residue was then concentrated and the crude material was purified by silica column chromatography (DCM/MeOH=25:1). All fractions found to contain product by TLC (DCM/MeOH=25:1, Rf=0.6) were combined and concentrated to yield a dark red solid of 4-ethoxypyridine 1-oxide (20 g, 101 mmol, 50% yield). 1H NMR (400 MHz, MeOH-d4) δ 8.20 (d, J=7.6 Hz, 2H), 7.12 (d, J=7.6 Hz, 2H), 4.18 (q, J=7.2 Hz, 2H), 1.42 (t, J=6.8 Hz, 3H); ES-LCMS m/z: 140.0 (M+H).

Aufarbeitung

  1. concentrationThe reaction residue was then concentrated
  2. customthe crude material was purified by silica column chromatography (DCM/MeOH=25:1)
  3. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-31c22387772a4f13a13992594843d037
Quelldatensatz
uspto-grants-2016_07
Patentnummer
US09382238B2

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