Hydrochloride methanol → N-(5-Isoquinolyl)-N'-methyl-1,3-propylenediamine hydrochloride
Reaktionsgleichung
C(O[C:6]([N:8](C)[CH2:9][CH2:10][CH2:11][NH:12][C:13]1[CH:22]=[CH:21][CH:20]=[C:19]2[C:14]=1[CH:15]=[CH:16][N:17]=[CH:18]2)=O)(C)(C)C.[ClH:24].CO>>[ClH:24].[CH:18]1[C:19]2[C:14](=[C:13]([NH:12][CH2:11][CH2:10][CH2:9][NH:8][CH3:6])[CH:22]=[CH:21][CH:20]=2)[CH:15]=[CH:16][N:17]=1Komponenten
3
Versuchsvorschrift
According to the method of Example 1, Step C, deprotection was performed (room temperature, 31 hours) by using Intermediate 29 (325 mg) and 10% hydrogen chloride/methanol solution (5 ml). The solvent was evaporated under reduced pressure, and the residue was added with methanol (1 ml) and diethyl ether (3 ml). The deposited precipitates were collected by filtration and washed with diethyl ether to obtain the title compound (273 mg) as light yellow powdery solid.
Aufarbeitung
- custom(room temperature, 31 hours)
- custom