N-(tert-Butoxycarbonyl)-1,5-diaminopentane → N-(tert-butoxycarbonyl)-N'-(5-isoquinolyl)-pentamethylenediamine

Beteiligte Stoffe

Reaktionsbedingungen

Reaktionsschritte

Under nitrogen atmosphere, a suspension of 5-bromoisoquinoline (245 mg), tris(dibenzylideneacetone)palladium(0) (56 mg), 2-(di-tert-butylphosphino)biphenyl (69 mg), N-(5-aminopentyl)carbamic acid tert-butyl ester (282 mg, Tokyo Kasei Kogyo) and sodium tert-butoxide (160 mg) in toluene was stirred with heating at 70° C. for 4.5 hours. The reaction mixture was cooled to room temperature and purified by silica gel column chromatography (n-hexane:ethyl acetate=1:1) to obtain the title compound (327 mg).

Herkunft & Nachweise