Aniline → 1-amino-N-(6-methyl-1-((3-(trifluoromethyl)phenyl)amino)isoquinolin-5-yl)isoquinoline-5-carboxamide

HRID 1051272

Reaktionsgleichung

Reaktionsgleichung von HRID 1051272
C([NH:5][C:6]1[C:15]2[CH:14]=[CH:13][CH:12]=[C:11]([C:16]([NH:18][C:19]3[CH:24]=[C:23]([C:25](=O)[NH:26][C:27]4[CH:32]=[CH:31][CH:30]=[C:29]([C:33]([F:36])([F:35])[F:34])[CH:28]=4)[CH:22]=[CH:21][C:20]=3[CH3:38])=[O:17])[C:10]=2[CH:9]=[CH:8][N:7]=1)(C)(C)C.CC1C=CC2C(NC3C=CC=C(C(F)(F)F)C=3)=[N:45][CH:44]=[CH:43]C=2C=1N.NC1C=CC=CC=1>>[NH2:5][C:6]1[C:15]2[CH:14]=[CH:13][CH:12]=[C:11]([C:16]([NH:18][C:19]3[C:20]([CH3:38])=[CH:21][CH:22]=[C:23]4[C:24]=3[CH:43]=[CH:44][N:45]=[C:25]4[NH:26][C:27]3[CH:32]=[CH:31][CH:30]=[C:29]([C:33]([F:35])([F:34])[F:36])[CH:28]=3)=[O:17])[C:10]=2[CH:9]=[CH:8][N:7]=1

Komponenten

4

Edukt 3

HCID 6115AnilineHCID 444789036-methyl-N1-(3-(trifluoromethyl)phenyl)isoquinoline-1,5-diamineHCID 1180907961-(t-butylamino)-N-(2-methyl-5-((3-(trifluoromethyl)phenyl)carbamoyl)phenyl)isoquinoline-5-carboxamide

Produkt 1

HCID 1180907981-amino-N-(6-methyl-1-((3-(trifluoromethyl)phenyl)amino)isoquinolin-5-yl)isoquinoline-5-carboxamideAusbeute 2 %

Versuchsvorschrift

The procedures of Steps (3) and (4) of Example 2 were repeated step by step, except for using 6-methyl-N1-(3-(trifluoromethyl)phenyl)isoquinoline-1,5-diamine obtained in Step (2) above instead of aniline in Step (3) of Example 1 to obtain the title compound (1.0 mg, 2%).

Quellen und Nachweise

ORD-Eintrag
ord-f88f749ceefb4e538d8fb2221f7d6f60
Quelldatensatz
uspto-grants-2016_07
Patentnummer
US09388165B2

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