Flumexadol → HCID 118323819, Verbindung

HRID 1051388Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1051388
[F:1][C:2]([F:16])([F:15])[C:3]1[CH:4]=[C:5]([CH:9]2[O:14][CH2:13][CH2:12][NH:11][CH2:10]2)[CH:6]=[CH:7][CH:8]=1.[F:17][C:18]([F:26])([F:25])[C:19](=[CH2:24])[C:20]([O:22][CH3:23])=[O:21]>>[F:17][C:18]([F:26])([F:25])[CH:19]([CH2:24][N:11]1[CH2:12][CH2:13][O:14][CH:9]([C:5]2[CH:6]=[CH:7][CH:8]=[C:3]([C:2]([F:1])([F:15])[F:16])[CH:4]=2)[CH2:10]1)[C:20]([O:22][CH3:23])=[O:21]

Komponenten

3

Edukt 2

HCID 65774FlumexadolHCID 2782391Methyl 2-(trifluoromethyl)acrylate

Produkt 1

HCID 118323819HCID 118323819, Verbindung

Versuchsvorschrift

In a 5 mL round-bottomed flask, 2-(3-(trifluoromethyl)phenyl)morpholine (650 mg, 2.81 mmol) was combined with methyl 2-(trifluoromethyl)acrylate (650 mg, 4.22 mmol; added slowly) to give a colorless solution and stirred at room temperature for 50 min. The crude reaction mixture was concentrated in vacuo to give an oil. The crude material was purified by flash chromatography (silica gel, 40+S, 0% to 30% ethyl acetate in hexanes) to afford 850 mg (78%)(methyl 3,3,3-trifluoro-2-((2-(3-(trifluoromethyl)phenyl)morpholino)-methyl)propanoate as a clear liquid. MH+=386.

Aufarbeitung

  1. additionadded slowly)
  2. customto give a colorless solution
  3. customThe crude reaction mixture
  4. concentrationwas concentrated in vacuo
  5. customto give an oil
  6. customThe crude material was purified by flash chromatography (silica gel, 40+S, 0% to 30% ethyl acetate in hexanes)

Quellen und Nachweise

ORD-Eintrag
ord-2bef9af9fcde4139945c44cbef9bcdcf
Quelldatensatz
uspto-grants-2016_07
Patentnummer
US09388172B2

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