Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|
| Edukt | 5-Bromoisoquinoline | HCID 736487 | — |
| Edukt | 2-(Di-tert-butylphosphino)biphenyl | HCID 2734215 | — |
| Edukt | Sodium t-butoxide | HCID 23676156 | — |
| Edukt | HCID 178418966 | HCID 178418966 | — |
| Lösungsmittel | Toluene | HCID 1140 | — |
| Produkt | HCID 178418965 | HCID 178418965 | 77,1% |
Reaktionsschritte
Under nitrogen atmosphere, a suspension of 5-bromoisoquinoline (253 mg), tris(dibenzylideneacetone)palladium(0) (58 mg), 2-(di-tert-butylphosphino)biphenyl (74 mg), Intermediate 38 (311 mg) and sodium tert-butoxide (165 mg) in toluene was stirred with heating at 70° C. for 3 hours. The reaction mixture was cooled to room temperature and purified by silica gel column chromatography (n-hexane:ethyl acetate=1:1) to obtain the title compound (320 mg).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patentnummer | US07094789B2 |
|---|
| Quelldatensatz | uspto-grants-2006_08 |
|---|
| ORD ID | ord-62ca8446a3a044da8763ed93973f3667 |
|---|
| Quellennotiz | uspto-grants-2006_08 |
|---|
