3-Bromo-3'-(trifluoromethyl)benzanilide → 3-[2-(methylthio)-5,7-dihydro-6H-pyrrolo[3,4-d]pyrimidin-6-yl]-N-[3-(trifluoromethyl)phenyl]benzamide
Reaktionsgleichung
[CH3:1][S:2][C:3]1[N:4]=[CH:5][C:6]2[CH2:11][NH:10][CH2:9][C:7]=2[N:8]=1.Br[C:13]1[CH:14]=[C:15]([CH:29]=[CH:30][CH:31]=1)[C:16]([NH:18][C:19]1[CH:24]=[CH:23][CH:22]=[C:21]([C:25]([F:28])([F:27])[F:26])[CH:20]=1)=[O:17]>>[CH3:1][S:2][C:3]1[N:4]=[CH:5][C:6]2[CH2:11][N:10]([C:13]3[CH:14]=[C:15]([CH:29]=[CH:30][CH:31]=3)[C:16]([NH:18][C:19]3[CH:24]=[CH:23][CH:22]=[C:21]([C:25]([F:28])([F:27])[F:26])[CH:20]=3)=[O:17])[CH2:9][C:7]=2[N:8]=1Komponenten
3
Versuchsvorschrift
In a manner similar to that describe in Example 126, 2-(methylthio)-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidine and 3-Bromo-N-[3-(trifluoromethyl)phenyl]benzamide were converted to the title compound.
Quellen und Nachweise
- ORD-Eintrag
- ord-cb20b80f172c4f959ce54544b6454112
- Quelldatensatz
- uspto-grants-2016_07