Trifluoroacetic acid → 2-(3-Acetyl-1H-indazol-1-yl)acetic acid

HRID 1052098Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1052098
[C:1]([C:4]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[N:6]([CH2:13][C:14]([O:16]C(C)(C)C)=[O:15])[N:5]=1)(=[O:3])[CH3:2].C(O)(C(F)(F)F)=O>C(Cl)Cl.CO>[C:1]([C:4]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[N:6]([CH2:13][C:14]([OH:16])=[O:15])[N:5]=1)(=[O:3])[CH3:2]

Komponenten

5

Edukt 2

HCID 6422Trifluoroacetic acidHCID 68283733tert-butyl 2-(3-acetyl-1H-indazol-1-yl)acetate

Produkt 1

HCID 682847152-(3-Acetyl-1H-indazol-1-yl)acetic acid

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 887MethanolLösungsmittelHCID 6344DichloromethaneLösungsmittel2×

Versuchsvorschrift

To a solution of tert-butyl 2-(3-acetyl-1H-indazol-1-yl)acetate (4 g, 12.4 mmol) in CH2Cl2 (45 mL) was added TFA (15 mL, 195.0 mmol), and the reaction mixture was stirred at RT overnight. Then was then diluted with CH2Cl2 and MeOH, and volatiles were evaporated under reduced pressure to afford the title compound: MS: 219 [M+H]+; tR (HPLC conditions d): 2.78 min.

Aufarbeitung

  1. customwere evaporated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-c9ec591230b244e9bc7792b5d70bb29e
Quelldatensatz
uspto-grants-2016_07
Patentnummer
US09388199B2

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