Hydrochloric Acid → (S)-2-Amino-4,4-dimethylpentan-1-ol hydrochloride

HRID 1052136Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1052136
C(OC(=O)[NH:7][C@H:8]([CH2:14][OH:15])[CH2:9][C:10]([CH3:13])([CH3:12])[CH3:11])(C)(C)C.[ClH:17]>O1CCOCC1>[ClH:17].[NH2:7][C@@H:8]([CH2:9][C:10]([CH3:13])([CH3:12])[CH3:11])[CH2:14][OH:15]

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 58280489((S)-1-hydroxymethyl-3,3-dimethyl-butyl)-carbamic acid tert-butyl ester

Produkt 1

HCID 90020033(S)-2-Amino-4,4-dimethylpentan-1-ol hydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 312751,4-DioxaneLösungsmittel

Versuchsvorschrift

To a solution of ((S)-1-hydroxymethyl-3,3-dimethyl-butyl)-carbamic acid tert-butyl ester (200 mg, 0.605 mmol) in dioxane (4 mL) was added HCl (4N in dioxane, 6.05 mL, 24.21 mmol). The reaction mixture was stirred at RT overnight and concentrated to give the desired material as a white powder which was used without further purification in the next. 1H NMR (400 MHz, DMSO-d6) δ (ppm): 7.79 (bs, 3H), 5.37 (m, 1H), 3.60 (m, 1H), 3.40 (overlap with water, m, 1H), 3.09 (m, 1H), 1.47 (dd, 1H), 1.33 (dd, 1H), 0.92 (s, 9H).

Aufarbeitung

  1. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-1b8f75b3ea9843b1b6394e40b5659b2f
Quelldatensatz
uspto-grants-2016_07
Patentnummer
US09388199B2

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