2,4-Dimethoxybenzenesulfonyl chloride → 2,4-Dimethoxy-N-(3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)benzenesulfonamide
Reaktionsgleichung
[CH3:1][C:2]1([CH3:16])[C:6]([CH3:8])([CH3:7])[O:5][B:4]([C:9]2[CH:10]=[C:11]([CH:13]=[CH:14][CH:15]=2)[NH2:12])[O:3]1.[CH3:17][O:18][C:19]1[CH:24]=[C:23]([O:25][CH3:26])[CH:22]=[CH:21][C:20]=1[S:27](Cl)(=[O:29])=[O:28]>>[CH3:17][O:18][C:19]1[CH:24]=[C:23]([O:25][CH3:26])[CH:22]=[CH:21][C:20]=1[S:27]([NH:12][C:11]1[CH:13]=[CH:14][CH:15]=[C:9]([B:4]2[O:3][C:2]([CH3:16])([CH3:1])[C:6]([CH3:7])([CH3:8])[O:5]2)[CH:10]=1)(=[O:28])=[O:29]Komponenten
3
Versuchsvorschrift
3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)aniline (450 mg, 2.05 mmol, prepared as described at Wing Kin Chow et al. Chemistry—A European Journal, 2011, 17(25), 6913-6917) was treated with 2,4-dimethoxybenzene-1-sulfonyl chloride (850 mg, 3.5 mmol) according to the method described in Preparation 15b to give 568 mg (77% yield) of the title compound as an oil. Purity 99%.