Trifluoroacetic acid → Phenyl pyrrolidine-3-carboxylate

HRID 1053522Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1053522
N1CCCC1C(OC1C=CC=CC=1)=O.C(O)(C(F)(F)F)=O.[N:22]1(C(OC(C)(C)C)=O)[CH2:26][CH2:25][CH:24]([C:27]([O:29][C:30]2[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=2)=[O:28])[CH2:23]1>>[NH:22]1[CH2:26][CH2:25][CH:24]([C:27]([O:29][C:30]2[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=2)=[O:28])[CH2:23]1

Komponenten

4

Edukt 3

HCID 6422Trifluoroacetic acidHCID 15598566Phenyl pyrrolidine-2-carboxylateHCID 898737321-tert-Butyl 3-phenyl pyrrolidine-1,3-dicarboxylate

Produkt 1

HCID 69577543Phenyl pyrrolidine-3-carboxylate

Versuchsvorschrift

The compound 25 was prepared according to the method described for compound 23 employing TFA (0.66 mL, 8.58 mmol) and compound 24 (500 mg, 1.71 mmol) to give white solid compound. The compound was used without further purification after solvent removal.

Aufarbeitung

  1. customto give white solid compound
  2. customThe compound was used without further purification
  3. customafter solvent removal

Quellen und Nachweise

ORD-Eintrag
ord-0f001729c14f4ad6807ebbd1657c1e36
Quelldatensatz
uspto-grants-2016_07
Patentnummer
US09393306B2

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