Hydrochloride methanol → 4-(4-Methanesulfinyl-5-isoquinolyl)aminopiperidine hydrochloride

HRID 10537Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 10537
[CH3:1][S:2]([C:4]1[C:13]2[C:8](=[CH:9][CH:10]=[CH:11][C:12]=2[NH:14][CH:15]2[CH2:20][CH2:19][N:18](C(OC(C)(C)C)=O)[CH2:17][CH2:16]2)[CH:7]=[N:6][CH:5]=1)=[O:3].[ClH:28].CO>>[ClH:28].[CH3:1][S:2]([C:4]1[C:13]2[C:8](=[CH:9][CH:10]=[CH:11][C:12]=2[NH:14][CH:15]2[CH2:20][CH2:19][NH:18][CH2:17][CH2:16]2)[CH:7]=[N:6][CH:5]=1)=[O:3]

Komponenten

3

Edukt 2

HCID 21893726Hydrochloride methanolHCID 21979852HCID 21979852, Verbindung

Produkt 1

HCID 219797784-(4-Methanesulfinyl-5-isoquinolyl)aminopiperidine hydrochloride

Versuchsvorschrift

According to the method of Example 1, Step C, deprotection was performed (50° C., 2 hours) by using Intermediate 79 (138 mg) and 10% hydrogen chloride/methanol solution (3 ml). The reaction mixture was cooled to room temperature, and then the solvent was evaporated under reduced pressure. The residue was added with methanol (2 ml) and diethyl ether (6 ml). The deposited precipitates were collected by filtration and washed with diethyl ether to obtain the title compound (92.2 mg) as brown powdery solid.

Aufarbeitung

  1. custom(50° C., 2 hours)
  2. customthe solvent was evaporated under reduced pressure
  3. additionThe residue was added with methanol (2 ml) and diethyl ether (6 ml)
  4. customThe deposited precipitates
  5. filtrationwere collected by filtration
  6. washwashed with diethyl ether

Quellen und Nachweise

ORD-Eintrag
ord-6fb0dd10e1f9415d9ffb3aac8812cd63
Quelldatensatz
uspto-grants-2006_08
Patentnummer
US07094789B2

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