Sodium Hydroxide → HCID 89501036, Verbindung

HRID 1054126Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1054126
[Cl:1][C:2]1[C:3]([F:19])=[CH:4][C:5]([N:14]2[CH:18]=[N:17][N:16]=[N:15]2)=[C:6](/[CH:8]=[CH:9]/[C:10]([O:12]C)=[O:11])[CH:7]=1.[OH-].[Na+]>CO.C1COCC1>[Cl:1][C:2]1[C:3]([F:19])=[CH:4][C:5]([N:14]2[CH:18]=[N:17][N:16]=[N:15]2)=[C:6](/[CH:8]=[CH:9]/[C:10]([OH:12])=[O:11])[CH:7]=1

Komponenten

5

Edukt 2

HCID 14798Sodium HydroxideHCID 89501016HCID 89501016, Verbindung

Produkt 1

HCID 89501036HCID 89501036, VerbindungAusbeute 42,1 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 887MethanolLösungsmittelHCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

To Intermediate 5C (5 g, 17.7 mmol) in MeOH (50 mL) and THF (25 mL) was added 10% NaOH solution (25 mL). After 2 h, the reaction was concentrated and the residue was diluted with H2O. The pH was adjusted to 2 to 3 with 1.5 N HCl and the resultant solid was filtered and washed with petroleum ether to afford 2 g of Intermediate 5. MS (ESI) m/z: 269.0 (M+H)+.

Aufarbeitung

  1. concentrationthe reaction was concentrated
  2. additionthe residue was diluted with H2O
  3. filtrationthe resultant solid was filtered
  4. washwashed with petroleum ether

Quellen und Nachweise

ORD-Eintrag
ord-4785c029162a4d18af5a20ba47a14bdb
Quelldatensatz
uspto-grants-2016_07
Patentnummer
US09394276B2

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