Ethyl 2-(trifluoromethyl)-1,3-thiazole-4-carboxylate → [2-(Trifluoromethyl)-1,3-thiazol-4-yl]methanol

HRID 1054226

Reaktionsgleichung

Reaktionsgleichung von HRID 1054226
[F:1][C:2]([F:14])([F:13])[C:3]1[S:4][CH:5]=[C:6]([C:8](OCC)=[O:9])[N:7]=1.[H-].[H-].[H-].[H-].[Li+].[Al+3]>C1COCC1>[F:14][C:2]([F:1])([F:13])[C:3]1[S:4][CH:5]=[C:6]([CH2:8][OH:9])[N:7]=1

Komponenten

4

Edukt 2

HCID 20079591Ethyl 2-(trifluoromethyl)-1,3-thiazole-4-carboxylateHCID 21226445Aluminium lithium hydride

Produkt 1

HCID 20079604[2-(Trifluoromethyl)-1,3-thiazol-4-yl]methanolAusbeute 56 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

To a stirring solution of ethyl 2-(trifluoromethyl)thiazole-4-carboxylate (1.0 g, 4.44 mmol) in THF (10 ml) was added LiAlH4 (0.169 g, 4.44 mmol) at 0-10° C. and stirred for 1 h at RT. Reaction mixture was cooled and quenched with saturated sodium sulfate solution till precipitates observed. Precipitates obtained were filtered and filtrate was evaporated to get desired product in 56% yield.

Aufarbeitung

  1. customReaction mixture
  2. temperaturewas cooled
  3. customquenched with saturated sodium sulfate solution
  4. customtill precipitates
  5. customPrecipitates
  6. customobtained
  7. filtrationwere filtered
  8. customfiltrate was evaporated

Quellen und Nachweise

ORD-Eintrag
ord-d0e96f6c79d24a58a222558e0a7838af
Quelldatensatz
uspto-grants-2016_07
Patentnummer
US09394300B2

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