Phosphorus tribromide → 4-(Bromomethyl)-2-(trifluoromethyl)thiazole

HRID 1054227

Reaktionsgleichung

Reaktionsgleichung von HRID 1054227
[F:1][C:2]([F:11])([F:10])[C:3]1[S:4][CH:5]=[C:6]([CH2:8]O)[N:7]=1.P(Br)(Br)[Br:13]>C(Cl)Cl>[Br:13][CH2:8][C:6]1[N:7]=[C:3]([C:2]([F:11])([F:10])[F:1])[S:4][CH:5]=1

Komponenten

4

Edukt 2

HCID 24614Phosphorus tribromideHCID 20079604[2-(Trifluoromethyl)-1,3-thiazol-4-yl]methanol

Produkt 1

HCID 694413474-(Bromomethyl)-2-(trifluoromethyl)thiazoleAusbeute 36 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel2×

Versuchsvorschrift

To a stirring solution of (2-(trifluoromethyl)thiazol-4-yl)methanol (550 mg, 3.00 mmol) in DCM (5 ml) was added PBr3 (0.283 ml, 3.00 mmol) at 0-5° C. in 5-10 min. and stirring continued for 1 h. Reaction mixture was diluted with DCM and washed with water. Organic layer was separated and distilled out to get crude product which was column purified using 0-2% EtOAC in hexane to get title compound in 36% yield.

Aufarbeitung

  1. customReaction mixture
  2. washwashed with water
  3. customOrganic layer was separated
  4. distillationdistilled out
  5. customto get crude product which
  6. custompurified

Quellen und Nachweise

ORD-Eintrag
ord-b2c90fe60bc649b0aa3bc4837e7703bb
Quelldatensatz
uspto-grants-2016_07
Patentnummer
US09394300B2

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