Hydrochloride methanol → N-(4-vinyl-5-isoquinolyl)-1,4-cyclohexanediamine hydrochloride

HRID 10545Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 10545
C(OC([NH:8][CH:9]1[CH2:14][CH2:13][CH:12]([NH:15][C:16]2[CH:25]=[CH:24][CH:23]=[C:22]3[C:17]=2[C:18]([CH:26]=[CH2:27])=[CH:19][N:20]=[CH:21]3)[CH2:11][CH2:10]1)=O)(C)(C)C.[ClH:28].CO>>[ClH:28].[CH:26]([C:18]1[C:17]2[C:22](=[CH:23][CH:24]=[CH:25][C:16]=2[NH:15][CH:12]2[CH2:13][CH2:14][CH:9]([NH2:8])[CH2:10][CH2:11]2)[CH:21]=[N:20][CH:19]=1)=[CH2:27]

Komponenten

3

Edukt 2

HCID 21893726Hydrochloride methanolHCID 21979768N-(tert-butoxycarbonyl)-N'-(4-vinyl-5-isoquinolyl)-1,4-cyclohexanediamine

Produkt 1

HCID 21979839N-(4-vinyl-5-isoquinolyl)-1,4-cyclohexanediamine hydrochloride

Versuchsvorschrift

According to the method of Example 1, Step C, deprotection was performed (50° C., 2 hours) by using Intermediate 85 (85.5 mg) and 10% hydrogen chloride/methanol solution (2 ml). The reaction mixture was cooled to room temperature, and then the solvent was evaporated under reduced pressure. The residue was added with methanol (1 ml) and diethyl ether (3 ml). The deposited precipitates were collected by filtration and washed with diethyl ether to obtain the title compound (52.3 mg).

Aufarbeitung

  1. custom(50° C., 2 hours)
  2. customthe solvent was evaporated under reduced pressure
  3. additionThe residue was added with methanol (1 ml) and diethyl ether (3 ml)
  4. customThe deposited precipitates
  5. filtrationwere collected by filtration
  6. washwashed with diethyl ether

Quellen und Nachweise

ORD-Eintrag
ord-46e100f7ec384b35afcd5adf91303a2d
Quelldatensatz
uspto-grants-2006_08
Patentnummer
US07094789B2

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