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Potassium Carbonate → 5-(4-Acetylphenyl)-6-chloro-1H-indazole-3-carboxylic acid

HRID 1054811
Notizen
Druckvorschau

Reaktionsgleichung

Reaktionsgleichung von HRID 1054811
Br[C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][C:10]=1[Cl:11])[NH:7][N:6]=[C:5]2[C:12]([OH:14])=[O:13].[C:15]([C:18]1[CH:23]=[CH:22][C:21](B(O)O)=[CH:20][CH:19]=1)(=[O:17])[CH3:16].C(=O)([O-])[O-].[K+].[K+]>C1(C)C=CC=CC=1.CCO.C1C=CC(P(C2C=CC=CC=2)[C-]2C=CC=C2)=CC=1.C1C=CC(P(C2C=CC=CC=2)[C-]2C=CC=C2)=CC=1.Cl[Pd]Cl.[Fe+2]>[C:15]([C:18]1[CH:23]=[CH:22][C:21]([C:2]2[CH:3]=[C:4]3[C:8](=[CH:9][C:10]=2[Cl:11])[NH:7][N:6]=[C:5]3[C:12]([OH:14])=[O:13])=[CH:20][CH:19]=1)(=[O:17])[CH3:16]
KomponentenVersuchsvorschriftAufarbeitungQuellen und NachweiseNotizen zur Reaktion

Komponenten

7

Edukt 3

HCID 11430Potassium CarbonateHCID 37021224-Acetylphenylboronic acidHCID 866987915-bromo-6-chloro-1H-indazole-3-carboxylic acid

Produkt 1

HCID 866988035-(4-Acetylphenyl)-6-chloro-1H-indazole-3-carboxylic acidAusbeute 40 %

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 44119782
Bis(cyclopenta-1,4-dien-1-yl(diphenyl)phosphane);dichloropalladium;iron(2+)
Katalysator
HCID 702EthanolLösungsmittel
HCID 1140TolueneLösungsmittel

Versuchsvorschrift

To a mixture of 5-bromo-6-chloro-1H-indazole-3-carboxylic acid (200 mg, 0.73 mmol) and 4-acetylphenylboronic acid (131 mg, 0.80 mmol) in toluene (2 mL) and EtOH (1 mL) was added 2 N aqueous potassium carbonate solution (1.45 mL, 2.90 mmol). The resulting mixture was degassed with N2 for 10 minutes, treated with [1,1′-bis(diphenylphosphino)ferrocene]dichloropalladium(II) (29 mg, 0.036 mmol), and heated to reflux for 16 hours. The cooled reaction was quenched with saturated NH4Cl and the mixture was filtered. The filtrate was acidified with 1 N HCl to pH 5 and extracted with EtOAc. The organic layer was dried over Na2SO4 and concentrated in vacuo. The resulting crude material was purified by reverse phase chromatography (Biotage C18 column, 0-40% MeCN/water) to give the title compound (82 mg, 40% yield) as a solid. MS (ES+) 315.0 (M+H)+. 1H NMR (400 MHz, DMSO-d6) δ 8.14 (s, 1H), 8.01 (d, J=8.39 Hz, 2H), 7.82 (s, 1H), 7.57 (d, J=8.20 Hz, 2H), 2.60 (s, 3H).

Aufarbeitung

  1. customThe resulting mixture was degassed with N2 for 10 minutes
  2. temperatureheated
  3. temperatureto reflux for 16 hours
  4. customThe cooled reaction
  5. customwas quenched with saturated NH4Cl
  6. filtrationthe mixture was filtered
  7. extractionextracted with EtOAc
  8. dry with materialThe organic layer was dried over Na2SO4
  9. concentrationconcentrated in vacuo
  10. customThe resulting crude material was purified by reverse phase chromatography (Biotage C18 column, 0-40% MeCN/water)

Quellen und Nachweise

ORD-Eintrag
ord-c6893c9677404ff696f2a211b5d88a24
Quelldatensatz
uspto-grants-2016_07
DOI
10.6084/m9.figshare.5104873.v1
Patentnummer
US09394285B2

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