[CH3:1][C:2]([CH3:9])=[CH:3][C:4]([N:6]=C=S)=O.[CH3:10][NH:11][CH:12]1[CH2:14][CH2:13]1.C(=O)([O-])[O-].[Na+].[Na+].I[CH3:22].[CH3:23][NH:24][NH2:25]>O1CCCC1>[CH:12]1([N:11]([CH3:10])[C:23]2[N:6]=[C:4]([CH:3]=[C:2]([CH3:9])[CH3:1])[N:25]([CH3:22])[N:24]=2)[CH2:14][CH2:13]1To a solution of 3-methylbut-2-enoyl isothiocyanate (500 mg, 3.54 mmol, Eq: 1.00) in Tetrahydrofuran (3.5 ml) was added a solution of N-methylcyclopropanamine (264 mg, 3.72 mmol, Eq: 1.05) in Tetrahydrofuran (3.5 ml). The mixture was stirred for 30 minutes. Sodium carbonate (394 mg, 3.72 mmol, Eq: 1.05) and iodomethane (1.01 g, 443 μl, 7.08 mmol, Eq: 2) was added and stirred overnight at 70° C. The solvent was evaporated. Methylhydrazine (1.63 g, 1.86 ml, 35.4 mmol, Eq: 10) was added and the mixture was stirred for 2 hours at 100° C. MS showed just product peak. The crude material was applied on silica gel and purified by column chromatography using heptane/ethyl acetate (0-40% ethyl acetate) as eluent affording
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