1-methyl-3-(pyrrolidin-1-yl)-1H-1,2,4-triazole-5-carbaldehyde → 6-Chloro-2-(2-(1-methyl-3-(pyrrolidin-1-yl)-1H-1,2,4-triazol-5-yl)vinyl)-[1,2,4]triazolo[1,5-a]pyridine
Reaktionsgleichung
[Cl-].[Cl:2][C:3]1[CH:4]=[CH:5][C:6]2[N:7]([N:9]=[C:10]([CH2:12][P+](C3C=CC=CC=3)(C3C=CC=CC=3)C3C=CC=CC=3)[N:11]=2)[CH:8]=1.[CH3:32][N:33]1[C:37]([CH:38]=O)=[N:36][C:35]([N:40]2[CH2:44][CH2:43][CH2:42][CH2:41]2)=[N:34]1>>[Cl:2][C:3]1[CH:4]=[CH:5][C:6]2[N:7]([N:9]=[C:10]([CH:12]=[CH:38][C:37]3[N:33]([CH3:32])[N:34]=[C:35]([N:40]4[CH2:44][CH2:43][CH2:42][CH2:41]4)[N:36]=3)[N:11]=2)[CH:8]=1Komponenten
3
Edukt 2
Produkt 1
Versuchsvorschrift
The desired product was prepared in analogy to Example 1 g) from ((6-chloro-[1,2,4]triazolo[1,5-a]pyridin-2-yl)methyl)triphenylphosphonium chloride (170 mg, 366 μmol, Eq: 1.00) and 1-methyl-3-(pyrrolidin-1-yl)-1H-1,2,4-triazole-5-carbaldehyde (66.0 mg, 366 μmol, Eq: 1.00). 110 mg (91%) of the desired product were obtained as a light yellow solid. MS: m/z=330.4 (M+H+)