1-(2,2-Diethoxyethyl)-1'-(4-methoxybenzyl)-1H,1'H-3,4'-bipyrazol-5-amine → HCID 178490761, Verbindung

HRID 1055633

Reaktionsgleichung

Reaktionsgleichung von HRID 1055633
C(O[CH:4](OCC)[CH2:5][N:6]1[C:10]([NH2:11])=[CH:9][C:8]([C:12]2[CH:13]=[N:14][N:15]([CH2:17][C:18]3[CH:23]=[CH:22][C:21]([O:24][CH3:25])=[CH:20][CH:19]=3)[CH:16]=2)=[N:7]1)C>C(O)C.S(=O)(=O)(O)O>[CH3:25][O:24][C:21]1[CH:22]=[CH:23][C:18]([CH2:17][N:15]2[CH:16]=[C:12]([C:8]3[CH:9]=[C:10]4[NH:11][CH:4]=[CH:5][N:6]4[N:7]=3)[CH:13]=[N:14]2)=[CH:19][CH:20]=1

Komponenten

4

Edukt 1

HCID 866909601-(2,2-Diethoxyethyl)-1'-(4-methoxybenzyl)-1H,1'H-3,4'-bipyrazol-5-amine

Produkt 1

HCID 178490761HCID 178490761, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 702EthanolLösungsmittelHCID 1118Sulfuric AcidLösungsmittel

Versuchsvorschrift

In a microwave oven (Biotage Initiator, with Dynamic Field Tuning), 155 mg (0.40 mmol) of the compound of Example 2A in 0.4 ml of ethanol and 0.2 ml of 2 M sulphuric acid were heated at 120° C. for 15 min. The reaction was then purified directly by preparative HPLC (Method 11). The product fractions were concentrated and the residue was dried under high vacuum. This gave 54 mg (46% of theory) of the title compound.

Aufarbeitung

  1. customThe reaction was then purified directly by preparative HPLC (Method 11)
  2. concentrationThe product fractions were concentrated
  3. customthe residue was dried under high vacuum

Quellen und Nachweise

ORD-Eintrag
ord-f72c1db23d20489c994c6c8744136b83
Quelldatensatz
uspto-grants-2016_07
Patentnummer
US09394309B2

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