3-Cyano-5-(pentafluoro-lambda6-sulphanyl)benzoic acid → 3-Cyano-N-(3-{6-[1-(4-methoxybenzyl)-1H-pyrazol-4-yl]-3-methyl-1H-imidazo[1,2-b]pyrazol-1-yl}-4-methylphenyl)-5-(pentafluoro-lambda6-sulphanyl)benzamide

HRID 1055673Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1055673
[CH3:1][O:2][C:3]1[CH:31]=[CH:30][C:6]([CH2:7][N:8]2[CH:12]=[C:11]([C:13]3[CH:14]=[C:15]4[N:20]([C:21]5[CH:22]=[C:23]([CH:25]=[CH:26][C:27]=5[CH3:28])[NH2:24])[CH:19]=[C:18]([CH3:29])[N:16]4[N:17]=3)[CH:10]=[N:9]2)=[CH:5][CH:4]=1.[C:32]([C:34]1[CH:35]=[C:36]([CH:40]=[C:41]([S:43]([F:48])([F:47])([F:46])([F:45])[F:44])[CH:42]=1)[C:37](O)=[O:38])#[N:33]>>[C:32]([C:34]1[CH:35]=[C:36]([CH:40]=[C:41]([S:43]([F:47])([F:48])([F:44])([F:45])[F:46])[CH:42]=1)[C:37]([NH:24][C:23]1[CH:25]=[CH:26][C:27]([CH3:28])=[C:21]([N:20]2[C:15]3[N:16]([N:17]=[C:13]([C:11]4[CH:10]=[N:9][N:8]([CH2:7][C:6]5[CH:5]=[CH:4][C:3]([O:2][CH3:1])=[CH:31][CH:30]=5)[CH:12]=4)[CH:14]=3)[C:18]([CH3:29])=[CH:19]2)[CH:22]=1)=[O:38])#[N:33]

Komponenten

3

Edukt 2

HCID 896998123-Cyano-5-(pentafluoro-lambda6-sulphanyl)benzoic acidHCID 896998613-{6-[1-(4-Methoxybenzyl)-1H-pyrazol-4-yl]-3-methyl-1H-imidazo[1,2-b]pyrazol-1-yl}-4-methylaniline

Produkt 1

HCID 896997643-Cyano-N-(3-{6-[1-(4-methoxybenzyl)-1H-pyrazol-4-yl]-3-methyl-1H-imidazo[1,2-b]pyrazol-1-yl}-4-methylphenyl)-5-(pentafluoro-lambda6-sulphanyl)benzamide

Versuchsvorschrift

100 mg (0.24 mmol) of the compound of Example 9A and 66 mg (0.24 mmol) of the compound of Example 23A were reacted and worked up analogously to the procedure of Example 48A. This gave 153 mg (77% pure, 73% of theory) of the title compound.

Quellen und Nachweise

ORD-Eintrag
ord-78138ac84ec34b288cef3e9cb8e34952
Quelldatensatz
uspto-grants-2016_07
Patentnummer
US09394309B2

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