3-(4-Methylpiperazin-1-yl)-5-(pentafluoro-lambda6-sulphanyl)benzoic acid trifluoroacetate → 3-(4-Methylpiperazin-1-yl)-N-{4-methyl-3-[6-(pyridin-3-yl)-1H-imidazo[1,2-b]pyrazol-1-yl]-phenyl}-5-(pentafluoro-lambda6-sulphanyl)benzamide

HRID 1055715Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1055715
[CH3:1][C:2]1[CH:8]=[CH:7][C:5]([NH2:6])=[CH:4][C:3]=1[N:9]1[C:16]2[N:12]([N:13]=[C:14]([C:17]3[CH:18]=[N:19][CH:20]=[CH:21][CH:22]=3)[CH:15]=2)[CH:11]=[CH:10]1.FC(F)(F)C(O)=O.[CH3:30][N:31]1[CH2:36][CH2:35][N:34]([C:37]2[CH:38]=[C:39]([CH:43]=[C:44]([S:46]([F:51])([F:50])([F:49])([F:48])[F:47])[CH:45]=2)[C:40](O)=[O:41])[CH2:33][CH2:32]1>>[CH3:30][N:31]1[CH2:36][CH2:35][N:34]([C:37]2[CH:38]=[C:39]([CH:43]=[C:44]([S:46]([F:51])([F:47])([F:48])([F:49])[F:50])[CH:45]=2)[C:40]([NH:6][C:5]2[CH:7]=[CH:8][C:2]([CH3:1])=[C:3]([N:9]3[C:16]4[N:12]([N:13]=[C:14]([C:17]5[CH:18]=[N:19][CH:20]=[CH:21][CH:22]=5)[CH:15]=4)[CH:11]=[CH:10]3)[CH:4]=2)=[O:41])[CH2:33][CH2:32]1

Komponenten

3

Edukt 2

HCID 896995603-(4-Methylpiperazin-1-yl)-5-(pentafluoro-lambda6-sulphanyl)benzoic acid trifluoroacetateHCID 897000234-Methyl-3-[6-(pyridin-3-yl)-1H-imidazo[1,2-b]pyrazol-1-yl]aniline

Produkt 1

HCID 897000813-(4-Methylpiperazin-1-yl)-N-{4-methyl-3-[6-(pyridin-3-yl)-1H-imidazo[1,2-b]pyrazol-1-yl]-phenyl}-5-(pentafluoro-lambda6-sulphanyl)benzamide

Versuchsvorschrift

50 mg (0.17 mmol) of the compound of Example 6A and 79.6 mg (0.17 mmol) of the compound of Example 17A were reacted and worked up analogously to the procedure of Example 16. This gave 82 mg (77% of theory) of the title compound.

Quellen und Nachweise

ORD-Eintrag
ord-9ed52056d2a141b3b83b5e215ae5a210
Quelldatensatz
uspto-grants-2016_07
Patentnummer
US09394309B2

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