3-tert-Butyl-5-(pyrrolidin-1-ylmethyl)benzoic acid trifluoroacetate → 3-tert-Butyl-N-{4-methyl-3-[6-(pyridin-3-yl)-1H-imidazo[1,2-b]pyrazol-1-yl]phenyl}-5-(pyrrolidin-1-ylmethyl)benzamide

HRID 1055737Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1055737
[CH3:1][C:2]1[CH:8]=[CH:7][C:5]([NH2:6])=[CH:4][C:3]=1[N:9]1[C:16]2[N:12]([N:13]=[C:14]([C:17]3[CH:18]=[N:19][CH:20]=[CH:21][CH:22]=3)[CH:15]=2)[CH:11]=[CH:10]1.FC(F)(F)C(O)=O.[C:30]([C:34]1[CH:35]=[C:36]([CH:40]=[C:41]([CH2:43][N:44]2[CH2:48][CH2:47][CH2:46][CH2:45]2)[CH:42]=1)[C:37](O)=[O:38])([CH3:33])([CH3:32])[CH3:31]>>[C:30]([C:34]1[CH:35]=[C:36]([CH:40]=[C:41]([CH2:43][N:44]2[CH2:45][CH2:46][CH2:47][CH2:48]2)[CH:42]=1)[C:37]([NH:6][C:5]1[CH:7]=[CH:8][C:2]([CH3:1])=[C:3]([N:9]2[C:16]3[N:12]([N:13]=[C:14]([C:17]4[CH:18]=[N:19][CH:20]=[CH:21][CH:22]=4)[CH:15]=3)[CH:11]=[CH:10]2)[CH:4]=1)=[O:38])([CH3:33])([CH3:31])[CH3:32]

Komponenten

3

Edukt 2

HCID 896998093-tert-Butyl-5-(pyrrolidin-1-ylmethyl)benzoic acid trifluoroacetateHCID 897000234-Methyl-3-[6-(pyridin-3-yl)-1H-imidazo[1,2-b]pyrazol-1-yl]aniline

Produkt 1

HCID 896997593-tert-Butyl-N-{4-methyl-3-[6-(pyridin-3-yl)-1H-imidazo[1,2-b]pyrazol-1-yl]phenyl}-5-(pyrrolidin-1-ylmethyl)benzamide

Versuchsvorschrift

35 mg (0.12 mmol) of the compound of Example 6A and 47 mg (0.12 mmol) of the compound of Example 22A were reacted and worked up analogously to the procedure of Example 16. This gave 55 mg (95% pure, 81% of theory) of the title compound.

Quellen und Nachweise

ORD-Eintrag
ord-f938a31b79ff49c0b537506c507a0489
Quelldatensatz
uspto-grants-2016_07
Patentnummer
US09394309B2

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