Stannane, tributyl(1-ethoxyethenyl)- → 8-(1-Ethoxyvinyl)-2-phenylquinoline

HRID 1056055

Reaktionsgleichung

Reaktionsgleichung von HRID 1056055
Br[C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:11]=1[N:10]=[C:9]([C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)[CH:8]=[CH:7]2.C([Sn](CCCC)(CCCC)[C:23]([O:25][CH2:26][CH3:27])=[CH2:24])CCC>C1(C)C=CC=CC=1.Cl[Pd](Cl)([P](C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1)[P](C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1>[CH2:26]([O:25][C:23]([C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:11]=1[N:10]=[C:9]([C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)[CH:8]=[CH:7]2)=[CH2:24])[CH3:27]

Komponenten

5

Edukt 2

HCID 619414Stannane, tributyl(1-ethoxyethenyl)-HCID 707004958-Bromo-2-phenylquinoline

Produkt 1

HCID 897820818-(1-Ethoxyvinyl)-2-phenylquinoline

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 178418476HCID 178418476, VerbindungKatalysatorHCID 1140TolueneLösungsmittel

Reaktionsbedingungen

Temperatur
80 °C

Versuchsvorschrift

In a sealed tube, to the suspension of 8-bromo-2-phenylquinoline (0.1 g, 0.352 mmol) in toluene (5 mL) was added PdCl2(PPh3)2 (0.012 g, 0.017 mmol) and tributyl (1-ethoxyvinyl)stannane (0.15 g, 0.422 mmol) under N2. The reaction was heated at 80° C. for 12 h, then cooled to RT. The solvent was removed and the crude material was used in the next step without further purification.

Aufarbeitung

  1. temperaturecooled to RT
  2. customThe solvent was removed
  3. customthe crude material was used in the next step without further purification

Quellen und Nachweise

ORD-Eintrag
ord-3b2faf61259145aea56ce4f3fa242058
Quelldatensatz
uspto-grants-2016_07
Patentnummer
US09394297B2

Verknüpfte Notizen

Wird geladen…