Hydrochloride methanol → HCID 178418896, Verbindung

HRID 10565

Reaktionsgleichung

Reaktionsgleichung von HRID 10565
C(OC([NH:8][C@H:9]1[CH2:14][CH2:13][C@H:12]([O:15][C:16]2[CH:25]=[CH:24][CH:23]=[C:22]3[C:17]=2[C:18]([Br:26])=[CH:19][N:20]=[CH:21]3)[CH2:11][CH2:10]1)=O)(C)(C)C.[ClH:27].CO>>[ClH:27].[Br:26][C:18]1[C:17]2[C:22](=[CH:23][CH:24]=[CH:25][C:16]=2[O:15][C@H:12]2[CH2:13][CH2:14][C@H:9]([NH2:8])[CH2:10][CH2:11]2)[CH:21]=[N:20][CH:19]=1

Komponenten

3

Edukt 2

HCID 21893726Hydrochloride methanolHCID 178418932HCID 178418932, Verbindung

Produkt 1

HCID 178418896HCID 178418896, Verbindung

Versuchsvorschrift

According to the method of Example 1, Step C, deprotection was performed (room temperature, 2 hours) by using Intermediate 121 (49.4 mg) and 10% hydrogen chloride/methanol solution (2 ml). The solvent was evaporated under reduced pressure, and the residue was added with methanol (0.5 ml) and diethyl ether (1.5 ml). The deposited precipitates were collected by filtration and washed with diethyl ether to obtain the title compound (44.3 mg).

Aufarbeitung

  1. custom(room temperature, 2 hours)
  2. customThe solvent was evaporated under reduced pressure
  3. additionthe residue was added with methanol (0.5 ml) and diethyl ether (1.5 ml)
  4. customThe deposited precipitates
  5. filtrationwere collected by filtration
  6. washwashed with diethyl ether

Quellen und Nachweise

ORD-Eintrag
ord-4e85aeddbc554fecbb78e2baa0b93744
Quelldatensatz
uspto-grants-2006_08
Patentnummer
US07094789B2

Verknüpfte Notizen

Wird geladen…