Potassium Carbonate → 1-Butyl-5-ethyluracil

HRID 1057253

Reaktionsgleichung

Reaktionsgleichung von HRID 1057253
[CH2:1]([C:3]1[C:4](=[O:10])[NH:5][C:6](=[O:9])[NH:7][CH:8]=1)[CH3:2].C(=O)([O-])[O-].[K+].[K+]>CN(C)C=O>[CH2:2]([N:7]1[CH:8]=[C:3]([CH2:1][CH3:2])[C:4](=[O:10])[NH:5][C:6]1=[O:9])[CH2:1][CH2:3][CH3:8]

Komponenten

4

Edukt 2

HCID 11430Potassium CarbonateHCID 732675-Ethyl-2,4(1H,3H)-pyrimidinedione

Produkt 1

HCID 186710321-Butyl-5-ethyluracilAusbeute 69 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Reaktionsbedingungen

Temperatur
120 °C

Versuchsvorschrift

To a solution of 5.6 g (40 mmol) of 5-ethyluracil in 60 ml of dimethylformamide, 5.5 g (40 mmol) of potassium carbonate and 2.3 ml (20 mmol) of n-iodobutane were added and stirred for 2 hours at 120° C. The reaction mixture was concentrated under reduced pressure and distributed between dichloromethane and aqueous solution of ammonium chloride, and the organic layer was concentrated under reduced pressure. The residue was adsorbed on a silica gel column and eluted with 30% ethyl acetate/hexane to obtain 2.7 g of 1-butyl-5-ethyluracil (Yield: 69%).

Aufarbeitung

  1. concentrationThe reaction mixture was concentrated under reduced pressure
  2. concentrationthe organic layer was concentrated under reduced pressure
  3. washeluted with 30% ethyl acetate/hexane

Quellen und Nachweise

ORD-Eintrag
ord-536f8196f59441eb9dc123a8eaaba2eb
Quelldatensatz
uspto-grants-2003_02
Patentnummer
USRE037979E1

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