7-(Dimethoxymethyl)-1,2,3,4-tetrahydro-1,8-naphthyridine → 5,6,7,8-Tetrahydro-1,8-naphthyridine-2-carbaldehyde

HRID 1057502Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1057502
C[O:2][CH:3](OC)[C:4]1[N:9]=[C:8]2[NH:10][CH2:11][CH2:12][CH2:13][C:7]2=[CH:6][CH:5]=1>FC(F)(F)C(O)=O>[NH:10]1[C:8]2=[N:9][C:4]([CH:3]=[O:2])=[CH:5][CH:6]=[C:7]2[CH2:13][CH2:12][CH2:11]1

Komponenten

3

Edukt 1

HCID 177501767-(Dimethoxymethyl)-1,2,3,4-tetrahydro-1,8-naphthyridine

Produkt 1

HCID 218737255,6,7,8-Tetrahydro-1,8-naphthyridine-2-carbaldehyde

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6422Trifluoroacetic acidLösungsmittel

Versuchsvorschrift

Dimethoxy-1,2,3,4-tetrahydropyridino[2,3-b]pyridin-7-ylmethane was dissolved in trifluoroacetic acid (14 mL) and stirred under nitrogen for 16 hrs. The mixture was quenched with saturated sodium bicarbonate, extracted with methylene chloride, dried over sodium sulfate, filtered, in vacuo and purified by flash chromatography (5% MeOH/CH2Cl2 ). EI-MS m/z 163 (M+H)+.

Aufarbeitung

  1. customThe mixture was quenched with saturated sodium bicarbonate
  2. extractionextracted with methylene chloride
  3. dry with materialdried over sodium sulfate
  4. filtrationfiltered, in vacuo
  5. custompurified by flash chromatography (5% MeOH/CH2Cl2 )

Quellen und Nachweise

ORD-Eintrag
ord-8f6e0f92abb04482939c2ad86e76e799
Quelldatensatz
uspto-grants-2003_02
Patentnummer
US06514964B1

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