Phthalic Anhydride → 2-Pyrimidin-4-yl-indan-1,3-dione

HRID 1057719

Reaktionsgleichung

Reaktionsgleichung von HRID 1057719
[C:1]1(=[O:11])[O:6][C:4](=O)[C:3]2=[CH:7][CH:8]=[CH:9][CH:10]=[C:2]12.[CH3:12][C:13]1[CH:18]=[CH:17][N:16]=[CH:15][N:14]=1>CO>[N:16]1[CH:17]=[CH:18][C:13]([CH:12]2[C:1](=[O:11])[C:2]3[C:3](=[CH:7][CH:8]=[CH:9][CH:10]=3)[C:4]2=[O:6])=[N:14][CH:15]=1

Komponenten

4

Edukt 2

HCID 6811Phthalic AnhydrideHCID 189224-Methylpyrimidine

Produkt 1

HCID 126190852-Pyrimidin-4-yl-indan-1,3-dione

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

7.87 g (53.1 mmol) phthalic acid anhydride and 22 ml (0.24 mol) 4-methylpyrimidine are stirred for 1 h at 140° C. and for 4 h at 210° C. The reaction mixture is then stirred with 15 ml methanol, filtered, and the residue washed with methanol. Further product is obtainable by evaporating the filtrate and stirring the residue with water m.p.: 168-169° C.); Anal. calc.(C13H8N2O2) C, 69.64%; H, 3.60%; N, 12.49%; found C, 69.8%; H 3.7%; N, 12.4%; FAB MS (M+H)+=225.

Aufarbeitung

  1. filtrationfiltered
  2. washthe residue washed with methanol
  3. customby evaporating the filtrate

Quellen und Nachweise

ORD-Eintrag
ord-17205e8268a04b8b8224c732d68756a4
Quelldatensatz
uspto-grants-2003_02
Patentnummer
US06514974B2

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