Reaktionsgleichung
COC1C=CC(C[NH:8][C:9]2[C:18]3[C:13](=[C:14]([NH:19][CH:20]4[CH2:25][CH2:24][N:23]([C:26]([O:28][C:29]([CH3:32])([CH3:31])[CH3:30])=[O:27])[CH2:22][CH2:21]4)[CH:15]=[CH:16][CH:17]=3)[CH:12]=[CH:11][N:10]=2)=CC=1>FC(F)(F)C(O)=O>[NH2:8][C:9]1[C:18]2[C:13](=[C:14]([NH:19][CH:20]3[CH2:25][CH2:24][N:23]([C:26]([O:28][C:29]([CH3:32])([CH3:31])[CH3:30])=[O:27])[CH2:22][CH2:21]3)[CH:15]=[CH:16][CH:17]=2)[CH:12]=[CH:11][N:10]=1Komponenten
3
Edukt 1
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
A solution of Intermediate 132 (270 mg) in 95% trifluoroacetic acid (5 ml) was stirred at 50° C. for 16 hours, and the solvent was evaporated under reduced pressure. The residue was added with dioxane (3 ml), 2 N aqueous sodium hydroxide (1 ml) and 2 di-t-butyl dicarbonate (393 mg) and stirred at room temperature for 1 hour. The solvent was evaporated under reduced pressure, and then the residue was purified by silica gel column chromatography (n-hexane:ethyl acetate:isopropylamine=5:5:1) to obtain the title compound (199 mg).
Aufarbeitung
- customthe solvent was evaporated under reduced pressure
- additionThe residue was added with dioxane (3 ml), 2 N aqueous sodium hydroxide (1 ml) and 2 di-t-butyl dicarbonate (393 mg)
- customThe solvent was evaporated under reduced pressure
- customthe residue was purified by silica gel column chromatography (n-hexane:ethyl acetate:isopropylamine=5:5:1)
Quellen und Nachweise
- ORD-Eintrag
- ord-b3e1fac3b5b54f7b92bfe077e81f3e7b
- Quelldatensatz
- uspto-grants-2006_08
- Patentnummer
- US07094789B2
Verknüpfte Notizen
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