Hydrochloride methanol → 4-(1-Amino-5-isoquinolyl)aminopiperidine

HRID 10582

Reaktionsgleichung

Reaktionsgleichung von HRID 10582
[NH2:1][C:2]1[C:11]2[C:6](=[C:7]([NH:12][CH:13]3[CH2:18][CH2:17][N:16](C(OC(C)(C)C)=O)[CH2:15][CH2:14]3)[CH:8]=[CH:9][CH:10]=2)[CH:5]=[CH:4][N:3]=1.Cl.CO>>[NH2:1][C:2]1[C:11]2[C:6](=[C:7]([NH:12][CH:13]3[CH2:18][CH2:17][NH:16][CH2:15][CH2:14]3)[CH:8]=[CH:9][CH:10]=2)[CH:5]=[CH:4][N:3]=1

Komponenten

3

Edukt 2

HCID 21893726Hydrochloride methanolHCID 219797874-(1-Amino-5-isoquinolyl)amino-1-(tert-butoxycarbonyl)piperidine

Produkt 1

HCID 219798644-(1-Amino-5-isoquinolyl)aminopiperidineAusbeute 71,7 %

Versuchsvorschrift

According to the method of Example 1, Step C, deprotection was performed (room temperature, 2 hours) by using Intermediate 133 (199 mg) and 10% hydrogen chloride/methanol solution (3 ml). The solvent was evaporated under reduced pressure, and the residue was added with methanol (1 ml) and diethyl ether (3 ml). The deposited precipitates were collected by filtration and washed with diethyl ether to obtain the title compound (101 mg).

Aufarbeitung

  1. custom(room temperature, 2 hours)
  2. customThe solvent was evaporated under reduced pressure
  3. additionthe residue was added with methanol (1 ml) and diethyl ether (3 ml)
  4. customThe deposited precipitates
  5. filtrationwere collected by filtration
  6. washwashed with diethyl ether

Quellen und Nachweise

ORD-Eintrag
ord-6a29741c4a614edab796fa123e380462
Quelldatensatz
uspto-grants-2006_08
Patentnummer
US07094789B2

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