Hydrochloric Acid → 2-(4-Chlorophenyl)nicotinic acid

HRID 1058319Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1058319
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:17]=[CH:16][CH:15]=[CH:14][C:9]=2[C:10]([O:12]C)=[O:11])=[CH:4][CH:3]=1.[OH-].[Na+].Cl>CO>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[N:17]=[CH:16][CH:15]=[CH:14][C:9]=2[C:10]([OH:12])=[O:11])=[CH:6][CH:7]=1

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 15318002Methyl 2-(4-chlorophenyl)nicotinate

Produkt 1

HCID 136013732-(4-Chlorophenyl)nicotinic acid

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

To a solution containing methyl 2-(4-chlorophenyl)nicotinate from the previous step (6.0 g, 24.2 mmol) in methyl alcohol (30 mL) was added 1N sodium hydroxide (29 mL). The mixture was stirred at room temperature overnight then neutralized with 1N hydrochloric acid (29 mL), evaporated in vacuo and dried overnight to yield the solid 2-(4-chlorophenyl)nicotinic acid (7.3 g, Theo. Yield=5.65 g, balance is NaCl; HPLC RT=2.17 min; LC-MS m/z=234).

Aufarbeitung

  1. customevaporated in vacuo
  2. customdried overnight

Quellen und Nachweise

ORD-Eintrag
ord-e522d7fb69e74804a905a8e2baac2be9
Quelldatensatz
uspto-grants-2003_02
Patentnummer
US06515011B2

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