Hydrochloric Acid → 2-Benzyl-3-[(1-{[(benzyloxy)carbonyl]amino}-2-phenylethyl)(hydroxy)phosphoryl]propanoic acid

HRID 1058760Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1058760
[OH:1][P:2]([CH:17]([NH:25][C:26]([O:28][CH2:29][C:30]1[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=1)=[O:27])[CH2:18][C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)([CH2:4][CH:5]([CH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)[C:6]([O:8]C)=[O:7])=[O:3].[OH-].[Na+].Cl>CO>[OH:3][P:2]([CH:17]([NH:25][C:26]([O:28][CH2:29][C:30]1[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=1)=[O:27])[CH2:18][C:19]1[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=1)([CH2:4][CH:5]([CH2:10][C:11]1[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=1)[C:6]([OH:8])=[O:7])=[O:1]

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 18668709Methyl 3-[hydroxy[2-phenyl-1-[[(phenylmethoxy)carbonyl)amino]ethyl]phosphinyl]-2-(phenylmethyl)propanoate

Produkt 1

HCID 186687012-Benzyl-3-[(1-{[(benzyloxy)carbonyl]amino}-2-phenylethyl)(hydroxy)phosphoryl]propanoic acidAusbeute 100 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

To a solution of 1 g (2.02 mmol) of methyl 3-[hydroxy[2-phenyl-1-[[(phenylmethoxy)carbonyl)amino]ethyl]phosphinyl]-2-(phenylmethyl)propanoate in 20 ml of methanol are added 20 ml of 1N sodium hydroxide. After stirring for 10 hours, the medium is acidified with 2N hydrochloric acid, the methanol is then evaporated off and the residue is extracted three times with ethyl acetate. The combined organic phases are washed with water, dried over sodium sulphate and evaporated. 0.97 g of product is recovered (yield=100%).

Aufarbeitung

  1. customthe methanol is then evaporated off
  2. extractionthe residue is extracted three times with ethyl acetate
  3. washThe combined organic phases are washed with water
  4. dry with materialdried over sodium sulphate
  5. customevaporated
  6. custom0.97 g of product is recovered (yield=100%)

Quellen und Nachweise

ORD-Eintrag
ord-a557920ddb094b44a10596349cbb5474
Quelldatensatz
uspto-grants-2003_02
Patentnummer
US06518260B1

Notizen zur Reaktion

Wird geladen…