Ethyl 2-(4-bromobenzyl)acrylate → Ethyl 3-(4-bromophenyl)-2-[[hydroxy[1-[[(phenylmethoxy)carbonyl]amino]ethyl]phosphinyl]methyl]propanoate
Reaktionsgleichung
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9](=[CH2:15])[C:10]([O:12][CH2:13][CH3:14])=[O:11])=[CH:4][CH:3]=1.[C:16]1([CH2:22][O:23][C:24]([NH:26][CH:27]([PH:29](=[O:31])[OH:30])[CH3:28])=[O:25])[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1>>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:8][CH:9]([CH2:15][P:29]([OH:31])([CH:27]([NH:26][C:24]([O:23][CH2:22][C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)=[O:25])[CH3:28])=[O:30])[C:10]([O:12][CH2:13][CH3:14])=[O:11])=[CH:6][CH:7]=1Komponenten
3
Versuchsvorschrift
The process is performed according to the operating conditions described in 5.3., starting with 2.6 g (9.67 mmol) of ethyl 4-bromo-α-methylenebenzenepropanoate and 2 g (8.23 mmol) of [1-[[(phenylmethoxy)carbonyl]amino]ethyl]phosphinic acid. 3.79 g of product are recovered (yield=90%).
Aufarbeitung
- custom3.79 g of product are recovered (yield=90%)